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Literature summary extracted from

  • Aerts, G.; Arrojo E Drigo, R.; Van Herck, S.L.; Sammels, E.; Mirebeau-Prunier, D.; Gereben, B.; Zeoeld, A.; Harney, J.W.; Huang, S.A.; Mulcahey, M.A.; Van der Geyten, S.; Van den Bergh, G.; Arckens, L.; Darras, V.M.; Zavacki, A.M.
    Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells (2009), Endocrinology, 150, 5171-5180.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.3 additional information interaction with peroxiredoxin 3, rate-limiting role in regeneration of type 3 iodothyronine deiodinase Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.99.3 transfection in HEK 293 cells Homo sapiens
1.21.99.4 transfection in HEK 293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 additional information decrease of deiodination about 50% in cells with knockdown of peroxiredoxin 3 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Homo sapiens
-
-
-
1.21.99.4 Homo sapiens P49895
-
-
1.21.99.4 Homo sapiens Q92813
-
-

Synonyms

EC Number Synonyms Comment Organism
1.21.99.3 type 3 iodothyronine deiodinase
-
 Homo sapiens
1.21.99.4 type 1 iodothyronine deiodinase
-
 Homo sapiens
1.21.99.4 type 2 iodothyronine deiodinase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.21.99.3 Homo sapiens no influence of peroxiredoxin 3 on expression oftype 3 iodothyronine deiodinase additional information

General Information

EC Number General Information Comment Organism
1.21.99.3 physiological function inactivates thyroid hormone, deiodination Homo sapiens
1.21.99.4 physiological function convert prohormone T4 to biologicalliy active T3 Homo sapiens